Geron Reports Presentations at American Society of Hematology Annual Meeting

Key Facts

• Data from Phase 2 clinical trials provide strong evidence that imetelstat targets telomerase to inhibit the uncontrolled proliferation of malignant stem and progenitor cells in myeloid hematologic malignancies resulting in malignant cell apoptosis and potential disease-modifying activity.
• About Geron Geron is a late-stage clinical biopharmaceutical company focused on the development and potential commercialization of a first-in-class telomerase inhibitor, imetelstat, in myeloid hematologic malignancies.
• Investors are cautioned that such statements, include, without limitation, those regarding: (i) that the Company believes the unique telomerase inhibition MOA of imetelstat has the potential to transform the standard of care in hematologic malignancies; (ii) that there may be a potential link between imetelstat activity and clinical efficacy in lower risk MDS; (iii) that there is strong evidence that imetelstat targets telomerase to inhibit the uncontrolled proliferation of malignant stem and progenitor cells in myeloid hematologic malignancies resulting in malignant cell apoptosis and potential disease-modifying activity; (iv) that the IMerge Phase 3 and IMpactMF clinical trials have registrational intent; (v) that the Company expects top-line results from IMerge Phase 3 in early January 2023; (vi) that there may be additional potential applications for imetelstat in hematologic malignancies; and (vii) other statements that are not historical facts, constitute forward-looking statements.
• These risks and uncertainties include, without limitation, risks and uncertainties related to whether: (i) imetelstat demonstrates disease-modifying activity in clinical trials; (ii) regulatory authorities permit the further development of imetelstat; (iii) imetelstat demonstrates to regular authorities that it is safe and efficacious in Phase 3 clinical trials; (iv) Geron is able to expeditiously manage the delivery of the results of IMerge Phase 3 by early January 2023; and (v) any future efficacy or safety results cause the benefit-risk profile of imetelstat to become unacceptable.

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